Randy Peterman points out that FeedDemon 1.5 enables podcasting without an iPod. In addition to supporting synching downloaded enclosures to your iPod via iTunes, FeedDemon also supports syncing to any device that maps to a drive letter and/or supports Windows Media Player's automatic synching. This opens up podcasting to a lot of media devices.
More details are available in this section of FeedDemon's online help.